Journal of magnetic resonance imaging : JMRI · 2004
Diffusion tensor imaging in the diagnosis of primary lateral sclerosis.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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Uluğ Aziz M, Grünewald Thomas, Lin Michael T, Kamal Ayeesha K, Filippi Christopher G, Zimmerman Robert D, Beal M Flint
Аннотация
PURPOSE: To evaluate the utility of MR diffusion tensor imaging in diagnosing primary lateral sclerosis (PLS).
MATERIALS AND METHODS: Five patients who met clinical criteria for a diagnosis of PLS, and two patients with possible PLS of less than three years duration and eight normal volunteers were studied using MR diffusion tensor imaging.
RESULTS: All seven patients showed decreased diffusion anisotropy and increased diffusion constant in the PLIC, with complete separation from a normal control group, including patients early in the course of the illness.
CONCLUSION: Quantitative diffusion tensor imaging appears to be a useful test to detect upper motor neuron damage and hence to help to establish the diagnosis of PLS.
MATERIALS AND METHODS: Five patients who met clinical criteria for a diagnosis of PLS, and two patients with possible PLS of less than three years duration and eight normal volunteers were studied using MR diffusion tensor imaging.
RESULTS: All seven patients showed decreased diffusion anisotropy and increased diffusion constant in the PLIC, with complete separation from a normal control group, including patients early in the course of the illness.
CONCLUSION: Quantitative diffusion tensor imaging appears to be a useful test to detect upper motor neuron damage and hence to help to establish the diagnosis of PLS.