La Tunisie medicale · 2026
Arabic Translation and Adaptation of the CVID_QoL Questionnaire to Measure Health-RelatedQuality of Life of Adultswith Common Variable Immune Deficiency.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод в очереди
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Zridi Salim, Errami Abderrahmane, Baraket Leila, Moudatir Mina, Bousfiha Ahmed Aziz, Benhsain Ibtihal
Аннотация
INTRODUCTION: Common Variable Immune Deficiency (CVID) is the most frequent symptomatic inborn error of immunity, associated with recurrent infections, autoimmunity, and malignancy. These complications substantially impair health-related quality of life (HRQoL). To date, no disease-specific HRQoL instrument has been validated in Arabic. This study aimed to translate, culturally adapt, and validate the CVID_QoL questionnaire for Arabic-speaking patients.
METHODS: The CVID_QoL was translated and adapted into Arabic according to international cross-cultural guidelines. A pilot test was performed, followed by administration of the pre-final version to 20 adults with CVID at Abderrahim El Harouchi Hospital, Casablanca. Internal consistency was assessed using Cronbach's alpha, and test-retest reliability with intraclass correlation coefficients (ICC). Construct validity was evaluated through Pearson's correlations with the General Health Questionnaire-12 (GH-12) and the Short Form-36 (SF-36). Discriminant validity was tested using the Mann-Whitney U test across clinical subgroups.
RESULTS: The Arabic CVID_QoL showed high internal consistency (Cronbach's α = 0.91) and excellent test-retest reliability (ICC = 0.88). Convergent validity was confirmed by significant correlations between CVID_QoL domains and GH-12 and SF-36 scores (e.g., emotional functioning with SF-36 mental health, r = 0.65, p< 0.001). Discriminant validity was established by significantly lower scores among patients with recurrent infections, pulmonary complications, or autoimmunity (p< 0.05).
CONCLUSION: The Arabic CVID_QoL is a reliable and valid tool for measuring HRQoL in Arabic-speaking adults with CVID. It provides a valuable contribution for both clinical care and research. Larger, multicenter studies are recommended to further confirm its utility.
METHODS: The CVID_QoL was translated and adapted into Arabic according to international cross-cultural guidelines. A pilot test was performed, followed by administration of the pre-final version to 20 adults with CVID at Abderrahim El Harouchi Hospital, Casablanca. Internal consistency was assessed using Cronbach's alpha, and test-retest reliability with intraclass correlation coefficients (ICC). Construct validity was evaluated through Pearson's correlations with the General Health Questionnaire-12 (GH-12) and the Short Form-36 (SF-36). Discriminant validity was tested using the Mann-Whitney U test across clinical subgroups.
RESULTS: The Arabic CVID_QoL showed high internal consistency (Cronbach's α = 0.91) and excellent test-retest reliability (ICC = 0.88). Convergent validity was confirmed by significant correlations between CVID_QoL domains and GH-12 and SF-36 scores (e.g., emotional functioning with SF-36 mental health, r = 0.65, p< 0.001). Discriminant validity was established by significantly lower scores among patients with recurrent infections, pulmonary complications, or autoimmunity (p< 0.05).
CONCLUSION: The Arabic CVID_QoL is a reliable and valid tool for measuring HRQoL in Arabic-speaking adults with CVID. It provides a valuable contribution for both clinical care and research. Larger, multicenter studies are recommended to further confirm its utility.