Leukemia & lymphoma · 2024
A new scoring system to predict survival in elderly advanced stage Hodgkin lymphoma patients.
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Mehtap Özgür, Toptas Tayfur, Dal Mehmet S, Karadag Fatma Keklik, Atas Unal, Özsan Güner H, Sayınalp Nilgün, Saydam Guray, Uçar Mehmet Ali, Kırkızlar Hakkı Onur, Salim Ozan, Tekinalp Atakan, Özkalemkaş Fahir, Pepedi Funda, Akay Olga M, Kılıçaslan Emrah, Paydas Semra, Bozdağ Sinem Civriz, Yılmaz Mehmet, Karakus Volkan, Arikan Fatma Gecgel, Darçın Tahir, Erdogan Elcin, Cinar Erkin, Gürsoy Vildan, Durusoy Salih S, Birtaş Ateşoğlu Elif, Tombak Anıl, Büyükkurt Nurhilal, Özcan Muhit, Altuntaş Fevzi, Kaygusuz Atagündüz Işık, Ferhanoglu Burhan
Аннотация
Predictive prognostic scoring (PS) systems are not primarily applicable to elderly patients with classical Hodgkin lymphoma (cHL). The objective of this study was to develop a PS system for these patients. The derivation cohort (DC) was utilized for model development, consisting of 97 variables. The resulting algorithm was named as Hodgkin's Lymphoma Early Death in the Elderly within 12 months (HEDEL12). Internal and external validation cohorts (IVC and EVC) were employed for validation. A total of 286 patients were evaluated retrospectively. In DC 38 of 178 patients died within the first 12 months and overall survival (OS) at 12-month was 78.6%. Independent predictors of HEDEL12 were female sex, low albumin levels (<3.5 g/dL), and ECOG scores 2-4. According to HEDEL12 scores 0-1, OS at 12- months were 89.8% and 91.0% for IVC and EVC, respectively. The HEDEL12 scoring is useful in predicting the survival of advanced-stage cHL patients.