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Войти в исследования Skin health and disease · 2026
The utility of biopsy in pyoderma gangrenosum: a retrospective cohort study.
СтатьяНазвание и аннотация: Перевод в очереди
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Moore Angel M, Karch Jamie L, Bradley Katherine E, Stevanovic Mirjana, Salem Iman, Parker Dylan J, Simmons Brian J
Аннотация
BACKGROUND: Pyoderma gangrenosum (PG) is a rare skin condition characterized by chronic, painful ulcerations. It is considered a diagnosis of exclusion, often resulting in diagnostic delay. Histological results in PG, even when biopsied despite a risk of pathergy, are nonspecific.
OBJECTIVES: To examine retrospectively the utility of biopsies in the diagnosis of 58 patients treated for PG.
METHODS: Medical records were reviewed to compare biopsy results versus the efficacy of diagnostic rating systems (Delphi, Su, PARACELSUS).
RESULTS: Among 58 patients, 26 (45%) underwent biopsies, with only 10 (38%) contributing to a PG diagnosis. As a single-centre and retrospective study, documentation style and sample size limit generalizability.
CONCLUSIONS: Given risk of pathergy, nonspecific histopathological findings and low sensitivity, in our opinion, based on this small sample size, biopsies have limited diagnostic value for PG.
OBJECTIVES: To examine retrospectively the utility of biopsies in the diagnosis of 58 patients treated for PG.
METHODS: Medical records were reviewed to compare biopsy results versus the efficacy of diagnostic rating systems (Delphi, Su, PARACELSUS).
RESULTS: Among 58 patients, 26 (45%) underwent biopsies, with only 10 (38%) contributing to a PG diagnosis. As a single-centre and retrospective study, documentation style and sample size limit generalizability.
CONCLUSIONS: Given risk of pathergy, nonspecific histopathological findings and low sensitivity, in our opinion, based on this small sample size, biopsies have limited diagnostic value for PG.