Cryptosporidium MVP1, modulates intestinal microvilli by interacting with host EBP50 and CDC42.

Cryptosporidium causes diarrhea globally, with limited treatment options. Host-parasite interactions are incompletely understood. Rodrigues et al. identified MVP1, one of a family of six exported microvilli proteins, and a new Cryptosporidium virulence determinant which interacts with host cell MBP50 and CDC42 to induce elongation of intestinal epithelial cell microvilli.