Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
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Britton Julie A, Khan Aneire E, Rohrmann Sabine, Becker Nikolaus, Linseisen Jakob, Nieters Alexandra, Kaaks Rudolf, Tjønneland Anne, Halkjaer Jytte, Severinsen Marianne Tang, Overvad Kim, Pischon Tobias, Boeing Heiner, Trichopoulou Antonia, Kalapothaki Victoria, Trichopoulos Dimitrios, Mattiello Amalia, Tagliabue Giovanna, Sacerdote Carlotta, Peeters Petra H M, Bueno-de-Mesquita H Bas, Ardanaz Eva, Navarro Carmen, Jakszyn Paula, Altzibar Jone M, Hallmans Göran, Malmer Beatrice, Berglund Göran, Manjer Jonas, Allen Naomi, Key Timothy, Bingham Sheila, Besson Hervé, Ferrari Pietro, Jenab Mazda, Boffetta Paolo, Vineis Paolo, Riboli Elio
Аннотация
DESIGN AND METHODS: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics.
RESULTS: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14-1.98) for highest versus lowest quartile; p-trend < 0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05).
CONCLUSIONS: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.