American journal of otolaryngology · 2024
Outcomes of free flap reconstruction for mandibular ORN: Systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Farsi Soroush, Benafield Anna, Dorman Jade, Gardner James Reed, Hairston Hayden C, Rereddy Rohan S, Nakanishi Hayato, King Deanne, Steelman Susan C, Vural Emre, Moreno Mauricio A, Sunde Jumin
Аннотация
OBJECTIVE: This study aims to evaluate the success rates and complications associated with different free flap donor sites used in surgical reconstruction for mandibular osteoradionecrosis, providing insights to aid clinical decision-making.
DATA SOURCES: MEDLINE, Embase, Cochrane, and Web of Science.
REVIEW METHODS: Comprehensive database searches were conducted up to October 2023. Three independent reviewers screened articles per PRISMA guidelines. This review is registered with PROSPERO (CRD42023456929). Meta-analysis, using inverse variance statistical method and a random effects model, was performed with OpenMeta software (Version 10.12, Brown University, USA). Study quality was assessed via the methodological index for non-randomized studies (MINORS).
RESULTS: Nineteen full-text articles met inclusion criteria, encompassing 397 patients and 424 free flap procedures. Patients averaged 54.8 years old; 27.5 % were female. Squamous cell carcinoma was the main radiation indication (83.1 %). Flap types included fibula (63 %), iliac crest (36 %), scapula (3.7 %), and radial forearm (3.5 %). Symptoms of osteoradionecrosis appeared on average four years post-radiation therapy, with a mean dose of 6346 cGy. Pooled postoperative complication rate was 22.5 % (95 % CI 0.165-0.284, I2:48%). Radial forearm flaps had the lowest complication rate (13.5 %, 95 % CI 0.026-0.295, I2:0%), while scapula flaps had the highest (34.9 %, 95 % CI 0.039-0.66, I2:40.3 %). Fibula flaps had the lowest failure rate (3.3 %, 95 % CI 0.003-0.025, I2:0%), while iliac crest flaps had the highest (11.9 %, 95 % CI 0.022-0.260, I2:60.4 %).
CONCLUSION: The fibula is the preferred flap for mandibular reconstruction due to its low failure rate. Radial forearm flaps show the fewest complications. More robust, multi-institutional prospective studies are needed.
DATA SOURCES: MEDLINE, Embase, Cochrane, and Web of Science.
REVIEW METHODS: Comprehensive database searches were conducted up to October 2023. Three independent reviewers screened articles per PRISMA guidelines. This review is registered with PROSPERO (CRD42023456929). Meta-analysis, using inverse variance statistical method and a random effects model, was performed with OpenMeta software (Version 10.12, Brown University, USA). Study quality was assessed via the methodological index for non-randomized studies (MINORS).
RESULTS: Nineteen full-text articles met inclusion criteria, encompassing 397 patients and 424 free flap procedures. Patients averaged 54.8 years old; 27.5 % were female. Squamous cell carcinoma was the main radiation indication (83.1 %). Flap types included fibula (63 %), iliac crest (36 %), scapula (3.7 %), and radial forearm (3.5 %). Symptoms of osteoradionecrosis appeared on average four years post-radiation therapy, with a mean dose of 6346 cGy. Pooled postoperative complication rate was 22.5 % (95 % CI 0.165-0.284, I2:48%). Radial forearm flaps had the lowest complication rate (13.5 %, 95 % CI 0.026-0.295, I2:0%), while scapula flaps had the highest (34.9 %, 95 % CI 0.039-0.66, I2:40.3 %). Fibula flaps had the lowest failure rate (3.3 %, 95 % CI 0.003-0.025, I2:0%), while iliac crest flaps had the highest (11.9 %, 95 % CI 0.022-0.260, I2:60.4 %).
CONCLUSION: The fibula is the preferred flap for mandibular reconstruction due to its low failure rate. Radial forearm flaps show the fewest complications. More robust, multi-institutional prospective studies are needed.