Journal of the American Academy of Dermatology · 2015
Lymphomatoid papulosis: Treatment response and associated lymphomas in a study of 180 patients.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wieser Iris, Oh Chee Won, Talpur Rakhshandra, Duvic Madeleine
Аннотация
BACKGROUND: Lymphomatoid papulosis (LyP) is a CD30(+) lymphoproliferative disorder, with a self-regressing clinical course and malignant histopathology.
OBJECTIVE: The aim of this study was to evaluate characteristics, risk factors, associated malignancies, long-term outcome, and treatment of LyP in a large cohort representing the experience of the MD Anderson Cancer Center.
METHODS: Patient charts and clinical and histopathologic data of 180 patients with LyP were retrospectively assessed.
RESULTS: A total of 56.7% of patients was men. Histologic subtype A was found in 47.2%, type B in 17.2%, type C in 22.8%, type D in 7.8%, type E in 0.6%, and mixed subtype in 4.4% of the patients. One hundred fourteen lymphomas were observed in 93 patients, with mycosis fungoides (61.4%) and anaplastic large cell lymphoma (26.3%) being the most common forms. Risk factors for development of lymphoma included sex and histologic subtype. Number of lesions and symptom severity were not associated with lymphoma development. Patients with type D were less likely to have lymphomas. Treatment provided symptomatic relief but did not prevent progression to lymphoma.
LIMITATIONS: The limitation of this study is the retrospective study design.
CONCLUSION: Patients with LyP are at increased risk of associated lymphomas. Thorough patient counseling is needed and long follow-up periods are required to detect and treat secondary lymphomas.
OBJECTIVE: The aim of this study was to evaluate characteristics, risk factors, associated malignancies, long-term outcome, and treatment of LyP in a large cohort representing the experience of the MD Anderson Cancer Center.
METHODS: Patient charts and clinical and histopathologic data of 180 patients with LyP were retrospectively assessed.
RESULTS: A total of 56.7% of patients was men. Histologic subtype A was found in 47.2%, type B in 17.2%, type C in 22.8%, type D in 7.8%, type E in 0.6%, and mixed subtype in 4.4% of the patients. One hundred fourteen lymphomas were observed in 93 patients, with mycosis fungoides (61.4%) and anaplastic large cell lymphoma (26.3%) being the most common forms. Risk factors for development of lymphoma included sex and histologic subtype. Number of lesions and symptom severity were not associated with lymphoma development. Patients with type D were less likely to have lymphomas. Treatment provided symptomatic relief but did not prevent progression to lymphoma.
LIMITATIONS: The limitation of this study is the retrospective study design.
CONCLUSION: Patients with LyP are at increased risk of associated lymphomas. Thorough patient counseling is needed and long follow-up periods are required to detect and treat secondary lymphomas.
Предметные рубрики MeSH
AdultAgedAntineoplastic AgentsCancer Care FacilitiesCohort StudiesCombined Modality TherapyDisease-Free SurvivalFemaleHumansImmunosuppressive AgentsKaplan-Meier EstimateLymphomaLymphoma, Large-Cell, AnaplasticLymphomatoid PapulosisMaleMiddle AgedMycosis FungoidesPhototherapyRetrospective StudiesRisk AssessmentSkin NeoplasmsSurvival RateTexasTreatment Outcome