Annals of neurology · 2006
Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Josephs Keith A, Whitwell Jennifer L, Boeve Bradley F, Shiung Maria M, Gunter Jeffrey L, Parisi Joseph E, Dickson Dennis W, Jack Clifford R
Аннотация
OBJECTIVE: To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans.
METHODS: This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects.
RESULTS: Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects.
INTERPRETATION: These rates provide a benchmark that can be used to monitor future treatment response in PSP.
METHODS: This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects.
RESULTS: Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects.
INTERPRETATION: These rates provide a benchmark that can be used to monitor future treatment response in PSP.