Fueling Death: The Metabolic Control of Ferroptosis.

Ferroptosis is a metabolically regulated, iron-dependent form of cell death driven by lipid peroxidation. This chapter dissects the core metabolic circuits that converge to determine ferroptotic susceptibility and explores the interplay between ferroptosis and other cell death programs, highlighting its physiological roles in development, immunity, and aging, and examines its dual function in disease. Emerging pharmacological strategies to modulate ferroptosis in cancer and degenerative conditions are discussed. By integrating metabolic checkpoints with redox biology, ferroptosis emerges as a therapeutic target with vast translational potential.