Vestnik rentgenologii i radiologii · 2015
[18F-FDG positron emission tomography in the diagnosis and staging of marginal zone non-Hodgkin lymphomas].
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Khodzhibekova M M, Tiutin L A, Kostenikov N A, Il'in N V, Vinogradova Iu N
Аннотация
OBJECTIVE: To investigate the diagnostic value of 18F-FDG positron emission tomography (PET) in the diagnosis and staging of marginal zone non-Hodgkin lymphomas (NHLs).
MATERIAL AND METHODS: Twenty-four patients with new-onset NHLs were examined. Extranodal MALT lymphoma, splenic marginal zone lymphoma (MZL), and nodal MZL lymphoma were diagnosed in 18, 3, and 3 patients, respectively. 18F-FDG PET was carried out by the standard protocol via whole-body examination, by estimating the standardized tracer uptake value (SUV(max)) in the abnormal foci.
RESULTS: Most (83.3%) of the examinees were found to have abnormal tracer hyperfixation foci. The mean SUV(max) was 5.05 ± 0.9. There was no correlation between SUV(max) in the tumor foci and their metabolic sizes (r = 0.1; p = 0.7). No significant differences between the mean SUV(max) were found in patients with different histological types of MZL (p > 0.05). Disease staging by PET and other diagnostic methods yielded contradictory results in three patients. The final analysis suggested that the stage had been correctly determined in all the 3 patients from PET findings.
CONCLUSION: The results of 18F-FDG PET suggest that it is of high iagnostic value in imag-ng marginal zone NHLs. The major advantage of PET is that it can accu-ately stage the disease, which can provide a ra-ionale for optimal treat-ent policy.
MATERIAL AND METHODS: Twenty-four patients with new-onset NHLs were examined. Extranodal MALT lymphoma, splenic marginal zone lymphoma (MZL), and nodal MZL lymphoma were diagnosed in 18, 3, and 3 patients, respectively. 18F-FDG PET was carried out by the standard protocol via whole-body examination, by estimating the standardized tracer uptake value (SUV(max)) in the abnormal foci.
RESULTS: Most (83.3%) of the examinees were found to have abnormal tracer hyperfixation foci. The mean SUV(max) was 5.05 ± 0.9. There was no correlation between SUV(max) in the tumor foci and their metabolic sizes (r = 0.1; p = 0.7). No significant differences between the mean SUV(max) were found in patients with different histological types of MZL (p > 0.05). Disease staging by PET and other diagnostic methods yielded contradictory results in three patients. The final analysis suggested that the stage had been correctly determined in all the 3 patients from PET findings.
CONCLUSION: The results of 18F-FDG PET suggest that it is of high iagnostic value in imag-ng marginal zone NHLs. The major advantage of PET is that it can accu-ately stage the disease, which can provide a ra-ionale for optimal treat-ent policy.