Cell reports · 2015
Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Anderson Courtney M, Kazantzis Melissa, Wang Jinshan, Venkatraman Subramaniam, Goncalves Renata L S, Quinlan Casey L, Ng Ryan, Jastroch Martin, Benjamin Daniel I, Nie Biao, Herber Candice, Van An-Angela Ngoc, Park Michael J, Yun Dawee, Chan Karen, Yu Angela, Vuong Peter, Febbraio Maria, Nomura Daniel K, Napoli Joseph L, Brand Martin D, Stahl Andreas
Аннотация
Brown adipose tissue (BAT) possesses the inherent ability to dissipate metabolic energy as heat through uncoupled mitochondrial respiration. An essential component of the mitochondrial electron transport chain is coenzyme Q (CoQ). While cells synthesize CoQ mostly endogenously, exogenous supplementation with CoQ has been successful as a therapy for patients with CoQ deficiency. However, which tissues depend on exogenous CoQ uptake as well as the mechanism by which CoQ is taken up by cells and the role of this process in BAT function are not well understood. Here, we report that the scavenger receptor CD36 drives the uptake of CoQ by BAT and is required for normal BAT function. BAT from mice lacking CD36 displays CoQ deficiency, impaired CoQ uptake, hypertrophy, altered lipid metabolism, mitochondrial dysfunction, and defective nonshivering thermogenesis. Together, these data reveal an important new role for the systemic transport of CoQ to BAT and its function in thermogenesis.