Frontiers in bioengineering and biotechnology · 2026
Hierarchical inverse opal hydrogel coatings for superhydrophobic, antibacterial, and drug-responsive catheter interfaces.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Yuegao, Hou Yijun, Fei Kaihong, Fu Songchao, Cheng Li, Zhou Lei, Deng Huibiao, Hu Shuqin
Аннотация
INTRODUCTION: Catheter-related infections and biofouling remain critical challenges in clinical practice due to limited surface functionalities and rapid bacterial biofilm formation.
METHODS: We developed a universal bottom-up strategy to fabricate hierarchical inverse opal hydrogel coatings on medical catheters via dopamine-mediated substrate activation, dual-layer colloidal assembly, and polymer infiltration, followed by oil infusion to enable adaptive wettability and low-friction liquid mobility.
RESULTS: The coatings exhibited stress-responsive wetting transitions, structural-color-enabled visual monitoring of degradation, and tunable droplet adhesion by modulating pore geometry. In vitro tests showed 98.9% antibacterial efficiency against E. coli, together with excellent hemocompatibility, cytocompatibility, and in vivo biosafety.
DISCUSSION: By integrating passive antifouling, controlled drug release, and real-time structural feedback in a single interface, this platform provides a robust route toward infection-resistant and intelligent catheter devices.
METHODS: We developed a universal bottom-up strategy to fabricate hierarchical inverse opal hydrogel coatings on medical catheters via dopamine-mediated substrate activation, dual-layer colloidal assembly, and polymer infiltration, followed by oil infusion to enable adaptive wettability and low-friction liquid mobility.
RESULTS: The coatings exhibited stress-responsive wetting transitions, structural-color-enabled visual monitoring of degradation, and tunable droplet adhesion by modulating pore geometry. In vitro tests showed 98.9% antibacterial efficiency against E. coli, together with excellent hemocompatibility, cytocompatibility, and in vivo biosafety.
DISCUSSION: By integrating passive antifouling, controlled drug release, and real-time structural feedback in a single interface, this platform provides a robust route toward infection-resistant and intelligent catheter devices.