Molecular & cellular proteomics : MCP · 2020
Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases.
СтатьяПоддержка исследования: вне правительства СШАTwin StudyНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Martin Tiphaine C, Šimurina Mirna, Ząbczyńska Marta, Martinic Kavur Marina, Rydlewska Magdalena, Pezer Marija, Kozłowska Kamila, Burri Andrea, Vilaj Marija, Turek-Jabrocka Renata, Krnjajić-Tadijanović Milena, Trofimiuk-Müldner Małgorzata, Ugrina Ivo, Lityńska Anna, Hubalewska-Dydejczyk Alicja, Trbojevic-Akmacic Irena, Lim Ee Mun, Walsh John P, Pocheć Ewa, Spector Tim D, Wilson Scott G, Lauc Gordan
Аннотация
Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case-control study with several independent cohorts and over 3,000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1,2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody-dependent cell-mediated cytotoxicity previously associated with TPOAb levels.