How does ECT work? A new explanatory model and suggestions for non-convulsive applications.

In this article a new hypothesis is presented concerning the causal mechanism underlying electroconvulsive therapy (ECT). According to this model the antidepressant effect is caused by a change in sleep architecture triggered by the ictal events induced by ECT. This change in sleep architecture - a profound change in the neurophysiological and neurochemical state of the organism - is what causes the therapeutic effects of ECT and not any simple change in the release of neurotransmitters, neurotrophic factors and/or hormones. This realization also means that a comparable antidepressant effect could be achieved without the need of inducing seizures, but with the help of behavioral interventions that explicitly take aim at changing sleep architecture. The article presents and discusses evidence in favor of this thesis and also puts forth two simple, non-convulsive, applications of the theory.