European journal of hospital pharmacy : science and practice · 2018
Evaluation of the use, effectiveness and safety of tyrosine kinase inhibitors in chronic myelogenous leukaemia in a general university hospital.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Marquinez-Alonso Iratxe, Escudero-Vilaplana Vicente, Osorio Santiago, Rodriguez-Gonzalez Carmen G, González-Haba Eva, Sanjurjo-Sáez María
Аннотация
OBJECTIVES: To evaluate the use, effectiveness and safety of tyrosine kinase inhibitors (TKIs) for chronic myelogenous leukaemia (CML) in clinical practice.
METHODS: A retrospective longitudinal study of patients with CML who received TKIs for at least 6 months was performed. Endpoints to evaluate effectiveness were haematological, cytogenetic and molecular responses. Safety was assessed according to the occurrence of adverse events.
RESULTS: Sixty-two patients were included. All received imatinib as the initial TKI; 8% switched to nilotinib due to lack of major molecular response (MMR) to imatinib and 3% switched to dasatinib because of progression to blast crisis or lack of MMR. At the end of the study all patients had achieved at least a complete cytogenetic response. With regard to safety, in 11 patients the dose of imatinib was decreased and four patients switched to a second-generation TKI due to imatinib toxicity.
CONCLUSIONS: Considering the good responses of most patients and its better known safety profile, imatinib should remain a good option for first-line treatment of CML.
METHODS: A retrospective longitudinal study of patients with CML who received TKIs for at least 6 months was performed. Endpoints to evaluate effectiveness were haematological, cytogenetic and molecular responses. Safety was assessed according to the occurrence of adverse events.
RESULTS: Sixty-two patients were included. All received imatinib as the initial TKI; 8% switched to nilotinib due to lack of major molecular response (MMR) to imatinib and 3% switched to dasatinib because of progression to blast crisis or lack of MMR. At the end of the study all patients had achieved at least a complete cytogenetic response. With regard to safety, in 11 patients the dose of imatinib was decreased and four patients switched to a second-generation TKI due to imatinib toxicity.
CONCLUSIONS: Considering the good responses of most patients and its better known safety profile, imatinib should remain a good option for first-line treatment of CML.