ASM case reports · 2025
Expedited diagnosis of disseminated Mycobacterium kansasii infection using targeted (amplicon-based) next-generation sequencing in an immunocompromised patient.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Fuller Risa, Petersen Bruce E, Hussein Shafinaz, Salib Christian, Duffield Amy, Gaglia Rebecca, Gabrilove Janice L, Hernández Carolina, Ramirez Juan David, Jacobs Samantha E, Paniz-Mondolfi Alberto
Аннотация
BACKGROUND: Mycobacterium kansasii is typically associated with pulmonary disease and is an uncommon cause of disseminated infection and thus can be challenging to diagnose and treat.
CASE SUMMARY: We present a 59-year-old female with a history of renal cell carcinoma (RCC) and T-cell large granular lymphocytic leukemia (T-LGLL) who developed disseminated Mycobacterium kansasii infection. Targeted next-generation sequencing (tNGS) facilitated the rapid detection of M. kansasii from formalin-fixed, paraffin-embedded (FFPE) tissue, aiding in clinical decision-making prior to culture confirmation.
CONCLUSION: The case highlights the diagnostic challenges posed by overlapping clinical features and chronic granulomatous inflammation in immunocompromised patients, as well as the utility of amplicon-based sequencing in expediting diagnostic turnaround and guiding therapeutic interventions.
CASE SUMMARY: We present a 59-year-old female with a history of renal cell carcinoma (RCC) and T-cell large granular lymphocytic leukemia (T-LGLL) who developed disseminated Mycobacterium kansasii infection. Targeted next-generation sequencing (tNGS) facilitated the rapid detection of M. kansasii from formalin-fixed, paraffin-embedded (FFPE) tissue, aiding in clinical decision-making prior to culture confirmation.
CONCLUSION: The case highlights the diagnostic challenges posed by overlapping clinical features and chronic granulomatous inflammation in immunocompromised patients, as well as the utility of amplicon-based sequencing in expediting diagnostic turnaround and guiding therapeutic interventions.