Plasma Microbial Cell-Free DNA Sequencing for the Diagnosis of Chronic Disseminated Candidiasis in Patients with Hematologic Malignancies.

Diagnosis of chronic disseminated candidiasis (CDC) is frequently delayed because clinical manifestations are nonspecific and conventional diagnostic tests have limited sensitivity. We describe a series of 19 CDC cases in which plasma microbial cell-free DNA sequencing was performed due to diagnostic uncertainty. Results influenced antifungal management in most cases.