International journal of food science · 2026
The Effect of Ipomoea batatas on Glycemic Control and Lipid Profiles in Animal Models: A Systematic Review and Meta-Analysis.
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Kusuma Hapsari Sulistya, Sulchan Mohammad, H S Heri-Nugroho, Suhartono Suhartono, Afifah Diana Nur, Mahati Endang, Ludin Arimi Fitri Mat, Pramono Adriyan
Аннотация
BACKGROUND: Sweet potato (Ipomoea batatas), a fiber-rich food with a low glycemic index, has shown potential in regulating glucose and lipid metabolism. This systematic review and meta-analysis aimed to evaluate its effects on glycemic and lipid parameters in animal models of obesity and insulin resistance.
METHODS: Relevant experimental studies published in English were identified through PubMed, Scopus, Cochrane Library, and Embase, excluding in silico models. Data were extracted for fasting glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Standardized mean differences (SMDs) with 95% confidence intervals were calculated, and risk of bias (RoB) was assessed using the SYRCLE RoB tool. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO (CRD42025599301). The literature search was conducted from November 2024 to August 2025.
RESULTS: Ten studies involving 428 animals were included in the meta-analysis. The meta-analysis demonstrated that I. batatas administration significantly reduced fasting plasma glucose (SMD = -3.88; 95% CI: -5.63 to -2.13; p < 0.0001; I 2 = 87%) and improved lipid parameters, including reductions in total cholesterol, triglycerides, and LDL-C and an increase in HDL-C (SMD total cholesterol -21.5 [-38.49 to -4.55]; p = 0.01; I 2 = 93%; SMD triglycerides -4.83 [-9.07 to -0.60]; p = 0.03; I 2 = 93%; SMD LDL-C -9.86 [-19.21 to -0.50]; p = 0.04; I 2 = 96%; SMD HDL-C 11.13 [2.06 to 20.21]; p = 0.02; I 2 = 95%). These effects were observed for both leaf and root extracts.
CONCLUSION: Supplementation with I. batatas favorably influences fasting glucose and lipid profiles in animal models, suggesting its potential as a functional dietary component for improving metabolic health.
METHODS: Relevant experimental studies published in English were identified through PubMed, Scopus, Cochrane Library, and Embase, excluding in silico models. Data were extracted for fasting glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Standardized mean differences (SMDs) with 95% confidence intervals were calculated, and risk of bias (RoB) was assessed using the SYRCLE RoB tool. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO (CRD42025599301). The literature search was conducted from November 2024 to August 2025.
RESULTS: Ten studies involving 428 animals were included in the meta-analysis. The meta-analysis demonstrated that I. batatas administration significantly reduced fasting plasma glucose (SMD = -3.88; 95% CI: -5.63 to -2.13; p < 0.0001; I 2 = 87%) and improved lipid parameters, including reductions in total cholesterol, triglycerides, and LDL-C and an increase in HDL-C (SMD total cholesterol -21.5 [-38.49 to -4.55]; p = 0.01; I 2 = 93%; SMD triglycerides -4.83 [-9.07 to -0.60]; p = 0.03; I 2 = 93%; SMD LDL-C -9.86 [-19.21 to -0.50]; p = 0.04; I 2 = 96%; SMD HDL-C 11.13 [2.06 to 20.21]; p = 0.02; I 2 = 95%). These effects were observed for both leaf and root extracts.
CONCLUSION: Supplementation with I. batatas favorably influences fasting glucose and lipid profiles in animal models, suggesting its potential as a functional dietary component for improving metabolic health.