Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
Comprehensive evaluation and analysis of pituitary hormones in male patients with non-functional pituitary adenoma during the perioperative period.
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Zhong Jiansheng, Chen Yuyang, Yang Wenxian, Hou Pengwei, Li Jun, Li Ziqi, Li Haixiang, Wei Liangfeng, Wang Shousen
Аннотация
OBJECTIVE: To analyze perioperative hormonal changes in male patients with non-functioning pituitary adenomas undergoing transsphenoidal surgery and establish a method for assessing adenopituitary function.
METHODS: We retrospectively analyzed preoperative clinical and imaging data, and perioperative anterior pituitary hormone levels of 123 male non-functioning pituitary adenomas patients who underwent surgery from 2012 to 2022. Hormone scores were calculated using an inverse tangent function normalized to normal hormone levels (0-1). Total pituitary hormone score summed six hormones (GH, ACTH, TSH, PRL, FSH, LH) reflecting overall pituitary secretion. ROC curves and AUC were calculated for assessment.
RESULTS: Most hormone levels (except GH, FSH) and total scores decreased postoperatively in large/giant adenoma groups, recovering by 3 months. Significant preoperative and postoperative differences were found in GH, TSH, LH, and total scores (P < 0.05). TSH, PRL, FSH, and total scores showed significant time-related changes, while GH, ACTH, and LH remained stable. Total scores differed significantly between patients with and without preoperative hypopituitarism (P < 0.001 for ACTH, FSH, LH, TSH). Prediction models had AUCs of 0.755 and 0.636 for patients without and with preoperative hypopituitarism, respectively.
CONCLUSIONS: Male non-functioning pituitary adenomas patients experienced immediate postoperative hormonal drops, followed by gradual recovery. The total hormone score efficiently assessed pituitary function, simplifying complex hormonal dynamics.
METHODS: We retrospectively analyzed preoperative clinical and imaging data, and perioperative anterior pituitary hormone levels of 123 male non-functioning pituitary adenomas patients who underwent surgery from 2012 to 2022. Hormone scores were calculated using an inverse tangent function normalized to normal hormone levels (0-1). Total pituitary hormone score summed six hormones (GH, ACTH, TSH, PRL, FSH, LH) reflecting overall pituitary secretion. ROC curves and AUC were calculated for assessment.
RESULTS: Most hormone levels (except GH, FSH) and total scores decreased postoperatively in large/giant adenoma groups, recovering by 3 months. Significant preoperative and postoperative differences were found in GH, TSH, LH, and total scores (P < 0.05). TSH, PRL, FSH, and total scores showed significant time-related changes, while GH, ACTH, and LH remained stable. Total scores differed significantly between patients with and without preoperative hypopituitarism (P < 0.001 for ACTH, FSH, LH, TSH). Prediction models had AUCs of 0.755 and 0.636 for patients without and with preoperative hypopituitarism, respectively.
CONCLUSIONS: Male non-functioning pituitary adenomas patients experienced immediate postoperative hormonal drops, followed by gradual recovery. The total hormone score efficiently assessed pituitary function, simplifying complex hormonal dynamics.