Laparoscopic resection with organ preservation of recurrent well-differentiated retroperitoneal liposarcoma in long-term disease-free survival: a case report.

Despite a favorable prognosis, well-differentiated retroperitoneal liposarcoma (WDLPS) recurs frequently. Although extended resection is advocated, its survival benefit is unclear and organ-preservation may be considered. A 46-year-old woman underwent hysterectomy, left salpingo-oophorectomy, and retroperitoneal tumor resection for a pelvic mass diagnosed as WDLPS. Three years later, a recurrence involving the rectum, pelvic sidewall, and vaginal stump occurred. Considering the well-differentiated appearance of the tumor on imaging, its unclear origin, potential multicentricity, lack of evidence supporting extended resection, and the patient's desire to preserve the organs, we chose laparoscopic tumor resection with partial vaginectomy. We performed successful tumor removal with negative margins and transvaginal extraction using a specimen bag. Pathology confirmed recurrent WDLPS. The patient remained recurrence-free 6 years postoperatively. Laparoscopic organ-preserving surgery is a feasible minimally invasive option for treating recurrent WDLPS in appropriate patients. Individualized decision-making is essential because evidence for extended resection is lacking.