Feasibility study of a mixed reality tool for real 3D visualization and planning of left atrial appendage occlusion.

In left atrial appendage occlusion (LAAO), pre-procedural imaging is pivotal to describe the highly variable LAA anatomy and to guide the operator in device sizing and interventional planning. Multiplanar reconstruction and 3D rendering are used for the interpretation of 3D CT datasets. However, this method of review of such imaging, which is mediated by 2D screens, may be limited due to the lack of true 3D visualization of the structures of interest; Mixed Reality (MxR) may further improve the CT-based pre-procedural planning by allowing for real-3D visualizations with holographic replicas of anatomical models. In this manuscript we present a novel software based on MxR and we evaluated its feasibility on different LAA morphologies. The morphological analysis of the holographic anatomical models was successfully applied for all the patients (n ​= ​4) independently from the morphology and it was performed in less than 10 minutes. Our findings suggest that with further developments MxR could have the potential to become a pivotal tool in LAA occlusion planning thanks to the real-3D perception, possibly leading to a more accurate and faster planning phase.