Current drug targets · 2022
COVID-19 Induces Cytokine Storm and Dysfunctional Hemostasis.
ОбзорСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Charles Jermilia, Ploplis Victoria A
Аннотация
BACKGROUND: Infection with SARS-CoV-2 leads to COVID-19 which can manifest in various ways from asymptomatic or mild disease to acute respiratory distress syndrome. The occurrence of dysregulated inflammatory responses in the form of a cytokine storm has been reported in patients with severe COVID-19. Infection can also lead to dysfunctional hemostasis reflected in elevated circulating D-dimer and fibrin degradation products. Components of hemostasis and the immune system during infection can result in a procoagulation and/or proinflammatory state. The interplay between coagulation and inflammation has been elucidated in a number of diseases.
OBJECTIVE: In this article, we discuss the occurrence of cytokine storms and dysfunctional hemostasis induced in COVID-19.
METHODS: This review was written using literature from the past two to three years investigating coagulation and inflammation in COVID-19. Additional literature, both clinical and basic research, related to pathogen infection and host responses were also considered in this review.
RESULTS/CONCLUSIONS: Infection with SARS-CoV-2 can lead to dysregulated inflammatory responses that may be detrimental to the host. The increased expression of various inflammatory factors can ultimately create an environment that promotes thrombosis.
OBJECTIVE: In this article, we discuss the occurrence of cytokine storms and dysfunctional hemostasis induced in COVID-19.
METHODS: This review was written using literature from the past two to three years investigating coagulation and inflammation in COVID-19. Additional literature, both clinical and basic research, related to pathogen infection and host responses were also considered in this review.
RESULTS/CONCLUSIONS: Infection with SARS-CoV-2 can lead to dysregulated inflammatory responses that may be detrimental to the host. The increased expression of various inflammatory factors can ultimately create an environment that promotes thrombosis.