Movement disorders clinical practice · 2026
Digital Handwriting Reveals Motor Impairment, Dopaminergic Response, and Progression in Parkinson's Disease.
СтатьяНазвание и аннотация: Перевод в очереди
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Díaz-Feliz Lola, Faundez-Zanuy Marcos, Gennari Andrea, Sánchez-Reyes Alexia, Sanz-Cartagena Pilar, Arbelo-González José, García-Cabezas Miguel Ángel, García-Ruiz Pedro
Аннотация
BACKGROUND: Digital handwriting distinguishes PD patients from healthy controls but is rarely assessed quantitatively.
OBJECTIVES: To evaluate digital handwriting as an objective tool to assess motor impairment, dopaminergic response, and progression in PD.
METHODS: Participants (Healthy Controls, n = 52; De Novo PD Patients assessed at baseline and after 7 weeks, n = 50; PD Patients in OFF-ON states following inhaled levodopa, n = 26; PD Progression Patients, n = 60) wrote a standard sentence on a digitizing tablet.
RESULTS: De Novo PD Patients showed reduced handwriting speed and increased in-air time. Acute dopaminergic stimulation in OFF-ON states was associated with shorter in-surface and in-air time. Longer disease duration was associated with increased variability in speed and acceleration. Higher MDS-UPDRS Part III scores were associated with lower speed and acceleration.
CONCLUSIONS: Digital handwriting is an objective digital biomarker for quantifying PD dysgraphia and its response to dopaminergic treatment.
OBJECTIVES: To evaluate digital handwriting as an objective tool to assess motor impairment, dopaminergic response, and progression in PD.
METHODS: Participants (Healthy Controls, n = 52; De Novo PD Patients assessed at baseline and after 7 weeks, n = 50; PD Patients in OFF-ON states following inhaled levodopa, n = 26; PD Progression Patients, n = 60) wrote a standard sentence on a digitizing tablet.
RESULTS: De Novo PD Patients showed reduced handwriting speed and increased in-air time. Acute dopaminergic stimulation in OFF-ON states was associated with shorter in-surface and in-air time. Longer disease duration was associated with increased variability in speed and acceleration. Higher MDS-UPDRS Part III scores were associated with lower speed and acceleration.
CONCLUSIONS: Digital handwriting is an objective digital biomarker for quantifying PD dysgraphia and its response to dopaminergic treatment.