Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
A serial SPECT-CT study in a celiac disease patient with cerebellar ataxia and psychiatric symptoms.
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Schmidt Juliana J, Schmidt Guilherme J, Tolentino Julio C, Simoes Eunice N, Obongo Angela, Tolentino Yolanda, Coelho Francisco A, Landesmann Maria C P P, Fonseca Lea M B, Lacerda Glenda C B, Schmidt Sergio L
Аннотация
Celiac disease (CD) is an immune-mediated systemic disorder triggered by gluten and related prolamins in genetically predisposed individuals. Here, we described a case of a 31-year-old Caucasian woman who exhibited cerebellar and psychiatric dysfunctions. The patient underwent single-photon emission computed tomography (SPECT-CT) before and after a gluten-free diet (GFD). There was an improvement in cerebellar perfusion accompanied by a remission of cerebellar manifestations. The maintenance of the psychiatric manifestations was related to the persistence of the hypoperfusion in the frontal lobes. The patient's psychiatric symptoms did not change after 4 months under a GFD in the hospital. To our knowledge, this is the first case that shows the relationship between improvement in cerebellar perfusion and remission of cerebellar clinical manifestations in a CD patient under a GFD.