Molecular genetic analysis of early onset familial Alzheimer's disease.

Today, results of molecular genetic analyses of familial Alzheimer's disease are not only confusing to those not directly involved in this particular research field but, they are also extremely troublesome to those trying to elucidate the genetic basis of this devastating neurological disorder. Dr. St. George-Hyslop has provided an excellent review of the current research state, outlining the major problems hindering the molecular geneticists in reaching their final goal, namely isolation and characterization of the gene(s) predisposing to familial Alzheimer's disease. We feel confident that with additional work and further advances, many of these obstacles will be overcome and the genetic role in AD more clearly delineated.