Frontiers in veterinary science · 2026
Yeast culture derived from Jiang-flavor Baijiu distiller's grains enhances immune function and gut health in geese.
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Tao Pan, Zhang Fei, Li Yu-Jie, Chen Xiao-Jie, Zuo Yi-Ming, Peng Zhen-Hong, Ji Wei-Kuan, Lv Yan-Tao, Huang Yun-Mao
Аннотация
INTRODUCTION: This study evaluated the effects of dietary supplementation with Jiang-flavor Baijiu distiller's grains yeast culture (JBGC) on immune performance and intestinal health in geese.
METHODS: A total of 512 one-day-old Magang geese were randomly assigned to four dietary treatments 0% (control), 2%, 6%, or 10% JBGC with eight replicates per treatment and 16 birds per replicate, over a 70-day experimental period.
RESULTS: JBGC supplementation exhibited dose- and time-dependent effects on antioxidant and inflammatory responses. Compared with the control, 10% JBGC significantly reduced serum glutathione peroxidase activity at day 70 and total antioxidant capacity at day 28 (P < 0.05), whereas both 6% and 10% JBGC increased hepatic total superoxide dismutase activity (P < 0.05). Regarding inflammatory markers, 10% JBGC lowered serum IL-1β at day 70 (P < 0.05), and all JBGC-supplemented groups (2%, 6%, and 10%) showed significantly lower IL-8 levels than the control during the later phase (P < 0.05). Additionally, 6 and 10% JBGC elevated the anti-inflammatory cytokine IL-10 at day 70 (P < 0.05). JBGC also improved intestinal morphology and barrier function: 6 and 10% JBGC increased ileal villus height (P < 0.05); 10% JBGC enhanced duodenal length and weight, jejunal weight, and total small intestinal weight; and 6% JBGC upregulated the protein expression of occludin and claudin?5 (P < 0.05). Although cecal microbial alpha diversity did not differ significantly, several beneficial bacterial genera showed increasing trends.
DISCUSSION: These findings indicate that JBGC can positively modulate immune and intestinal health in geese by influencing antioxidant status, inflammatory cytokine profiles, intestinal morphology, and barrier integrity.
METHODS: A total of 512 one-day-old Magang geese were randomly assigned to four dietary treatments 0% (control), 2%, 6%, or 10% JBGC with eight replicates per treatment and 16 birds per replicate, over a 70-day experimental period.
RESULTS: JBGC supplementation exhibited dose- and time-dependent effects on antioxidant and inflammatory responses. Compared with the control, 10% JBGC significantly reduced serum glutathione peroxidase activity at day 70 and total antioxidant capacity at day 28 (P < 0.05), whereas both 6% and 10% JBGC increased hepatic total superoxide dismutase activity (P < 0.05). Regarding inflammatory markers, 10% JBGC lowered serum IL-1β at day 70 (P < 0.05), and all JBGC-supplemented groups (2%, 6%, and 10%) showed significantly lower IL-8 levels than the control during the later phase (P < 0.05). Additionally, 6 and 10% JBGC elevated the anti-inflammatory cytokine IL-10 at day 70 (P < 0.05). JBGC also improved intestinal morphology and barrier function: 6 and 10% JBGC increased ileal villus height (P < 0.05); 10% JBGC enhanced duodenal length and weight, jejunal weight, and total small intestinal weight; and 6% JBGC upregulated the protein expression of occludin and claudin?5 (P < 0.05). Although cecal microbial alpha diversity did not differ significantly, several beneficial bacterial genera showed increasing trends.
DISCUSSION: These findings indicate that JBGC can positively modulate immune and intestinal health in geese by influencing antioxidant status, inflammatory cytokine profiles, intestinal morphology, and barrier integrity.