Long working hours and risk of coronary heart disease and stroke: a systematic review and meta-analysis of published and unpublished data for 603,838 individuals.
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Kivimäki Mika, Jokela Markus, Nyberg Solja T, Singh-Manoux Archana, Fransson Eleonor I, Alfredsson Lars, Bjorner Jakob B, Borritz Marianne, Burr Hermann, Casini Annalisa, Clays Els, De Bacquer Dirk, Dragano Nico, Erbel Raimund, Geuskens Goedele A, Hamer Mark, Hooftman Wendela E, Houtman Irene L, Jöckel Karl-Heinz, Kittel France, Knutsson Anders, Koskenvuo Markku, Lunau Thorsten, Madsen Ida E H, Nielsen Martin L, Nordin Maria, Oksanen Tuula, Pejtersen Jan H, Pentti Jaana, Rugulies Reiner, Salo Paula, Shipley Martin J, Siegrist Johannes, Steptoe Andrew, Suominen Sakari B, Theorell Töres, Vahtera Jussi, Westerholm Peter J M, Westerlund Hugo, O'Reilly Dermot, Kumari Meena, Batty G David, Ferrie Jane E, Virtanen Marianna, IPD-Work Consortium
Аннотация
METHODS: We identified published studies through a systematic review of PubMed and Embase from inception to Aug 20, 2014. We obtained unpublished data for 20 cohort studies from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium and open-access data archives. We used cumulative random-effects meta-analysis to combine effect estimates from published and unpublished data.
FINDINGS: We included 25 studies from 24 cohorts in Europe, the USA, and Australia. The meta-analysis of coronary heart disease comprised data for 603,838 men and women who were free from coronary heart disease at baseline; the meta-analysis of stroke comprised data for 528,908 men and women who were free from stroke at baseline. Follow-up for coronary heart disease was 5·1 million person-years (mean 8·5 years), in which 4768 events were recorded, and for stroke was 3·8 million person-years (mean 7·2 years), in which 1722 events were recorded. In cumulative meta-analysis adjusted for age, sex, and socioeconomic status, compared with standard hours (35-40 h per week), working long hours (≥55 h per week) was associated with an increase in risk of incident coronary heart disease (relative risk [RR] 1·13, 95% CI 1·02-1·26; p=0·02) and incident stroke (1·33, 1·11-1·61; p=0·002). The excess risk of stroke remained unchanged in analyses that addressed reverse causation, multivariable adjustments for other risk factors, and different methods of stroke ascertainment (range of RR estimates 1·30-1·42). We recorded a dose-response association for stroke, with RR estimates of 1·10 (95% CI 0·94-1·28; p=0·24) for 41-48 working hours, 1·27 (1·03-1·56; p=0·03) for 49-54 working hours, and 1·33 (1·11-1·61; p=0·002) for 55 working hours or more per week compared with standard working hours (ptrend<0·0001).
INTERPRETATION: Employees who work long hours have a higher risk of stroke than those working standard hours; the association with coronary heart disease is weaker. These findings suggest that more attention should be paid to the management of vascular risk factors in individuals who work long hours.
FUNDING: Medical Research Council, Economic and Social Research Council, European Union New and Emerging Risks in Occupational Safety and Health research programme, Finnish Work Environment Fund, Swedish Research Council for Working Life and Social Research, German Social Accident Insurance, Danish National Research Centre for the Working Environment, Academy of Finland, Ministry of Social Affairs and Employment (Netherlands), US National Institutes of Health, British Heart Foundation.