International journal of cardiology · 2009
Paraoxonase-1 activity determination via paraoxon substrate yields no significant difference in mild hyperhomocysteinemia.
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Türkeli Hatice, Caycı Tuncer, Akgül Emin Özgür, Macit Enis, Yaman Halil, Aydın Ibrahim, Demirin Hilmi, Alacam Hasan, Ozkan Esin, Cakır Erdinç, Deren Ozgür, Erbil Mehmet Kemal, Kunak Z Ilker, Burat Kutlay, Akman Serif
Аннотация
Elevated plasma homocystein (Hcy) level has been recognized as an important risk factor for a number of cardiovascular diseases, peripheral arterial occlusive disease and venous thrombosis. A part of Hcy in the organism is turned to homocysteine thiolactone (HcyT) via a ring closure reaction, which gains rate in hyperhomocysteinemia, and in turn undergoes a hydrolytic reaction back to Hcy by paraoxonase enzyme (PON). Since this is a protective reflex action enzyme against hyperhomocysteinemia, we investigated how a mild hyperhomocysteinemic nutritional habit affected serum PON activity in a population-based study. The difference detected via enzymatic activity using the paraoxon substrate was statistically non-significant (p=0.19), suggesting a defective performance to reflect the expected significance. Determination of serum PON activity via substrate paraoxon yielded no significant difference in an acute mild hyperhomocysteinemic diet model in humans.