Revista clinica espanola · 1995
[The association between a cerebrovascular accident and peripheral arterial disease: a case-control study in Asturias, Spain].
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Caicoya Gómez-Morán M, Corrales Canel C, Lasheras Mayo C, Cuello Rocas R, Rodríguez Alvarez T
Аннотация
OBJECTIVE: To evaluate peripheral arterial disease (PAD) and total stroke, cortical infarction, deep infarction and cerebral hemorrhage.
BACKGROUND: The different manifestations of atherosclerotic disease, despite being considered a systemic disease, have different risk factors and complex associations between themselves. On the other hand, the relationship between stroke and PAD is poorly understood.
METHOD: Case-control and population based study of incidence. Place and time: Asturias, Spain, 1990-1992. Dependent variable: stroke, defined according to WHO criteria.
INDEPENDENT VARIABLE: PAD, defined according to clinical symptoms of intermittent claudication. Confounding potentials: age, sex, alcohol, smoking, arterial hypertension, hyperglycemia, heart disease. Analysis methods: bivariant comparisons and multivariant analysis by the logistic regression model.
SAMPLE SIZE: 458 cases and 470 controls.
RESULTS: PAD was associated with total stroke (OR: 3.4; 95% CI 1.7-7.3), cerebral infarction (OR: 3.2; 95% CI 1.5-6.8), cortical infarction (OR: 3.1; 95% CI 1.3-7.7) and intracerebral hemorrhage (5.0 95% CI 2.0-12.3) once adjusted for risk factors of these diseases. No association was found between small deep infarction and PAD.
CONCLUSIONS: The association between stroke and PAD possibly denotes similar substrates for both entities. The association of superficial infarction and PAD is postulated to be due to atherosclerotic involvement of large and medium sized arteries, while the association between PAD and cerebral hemorrhage is due to atherosclerotic involvement of small arteries.
BACKGROUND: The different manifestations of atherosclerotic disease, despite being considered a systemic disease, have different risk factors and complex associations between themselves. On the other hand, the relationship between stroke and PAD is poorly understood.
METHOD: Case-control and population based study of incidence. Place and time: Asturias, Spain, 1990-1992. Dependent variable: stroke, defined according to WHO criteria.
INDEPENDENT VARIABLE: PAD, defined according to clinical symptoms of intermittent claudication. Confounding potentials: age, sex, alcohol, smoking, arterial hypertension, hyperglycemia, heart disease. Analysis methods: bivariant comparisons and multivariant analysis by the logistic regression model.
SAMPLE SIZE: 458 cases and 470 controls.
RESULTS: PAD was associated with total stroke (OR: 3.4; 95% CI 1.7-7.3), cerebral infarction (OR: 3.2; 95% CI 1.5-6.8), cortical infarction (OR: 3.1; 95% CI 1.3-7.7) and intracerebral hemorrhage (5.0 95% CI 2.0-12.3) once adjusted for risk factors of these diseases. No association was found between small deep infarction and PAD.
CONCLUSIONS: The association between stroke and PAD possibly denotes similar substrates for both entities. The association of superficial infarction and PAD is postulated to be due to atherosclerotic involvement of large and medium sized arteries, while the association between PAD and cerebral hemorrhage is due to atherosclerotic involvement of small arteries.