Diabetes & metabolic syndrome · 2025
Incremental risk of developing type 2 diabetes mellitus (T2D) starts at low Body Mass Index (BMI) in Asian Indians: Analysis from India Heart Watch (IHW).
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Guptha Leena S, Gupta Rajeev, Sharma Krishna Kumar, Guptha Soneil
Аннотация
INTRODUCTION: A Body Mass Index (BMI) of 23 kg/m2 is recognized as an appropriate threshold for Asian Indians to diagnose overweight and obesity, conditions associated with an increased risk of developing type 2 diabetes (T2D). We assessed the incremental risk of T2D beginning at a BMI of 18.5 kg/m2, which is below the specified threshold.
METHODS: The secondary data employed in this analysis were initially gathered in the IHW study, which aimed to determine the nationwide prevalence of cardiovascular disease (CVD) risk factors among urban populations in medium-sized cities within large Indian regional states.
RESULTS: A linear association between BMI and T2D, as determined by the Mantel-Haenszel Test, demonstrated that each incremental increase of one unit in BMI significantly elevates the risk of T2D by 28 % (Odds Ratio = 1.28, 95 % Confidence Interval [1.19, 1.37], p < .0001), commencing at a threshold of 18.5 kg/m2. This finding refutes the null hypothesis of no correlation between BMI and T2D.
CONCLUSION: The results of this analysis suggest that a BMI exceeding 18.5 kg/m2 may serve as a threshold for identifying individuals at an increased risk of T2D and for developing preventive strategies within the urban Asian Indian population. Nonetheless, this threshold warrants confirmation through a longitudinal investigation involving individuals with normal blood glucose levels, with particular attention to its correlation with HbA1c.
METHODS: The secondary data employed in this analysis were initially gathered in the IHW study, which aimed to determine the nationwide prevalence of cardiovascular disease (CVD) risk factors among urban populations in medium-sized cities within large Indian regional states.
RESULTS: A linear association between BMI and T2D, as determined by the Mantel-Haenszel Test, demonstrated that each incremental increase of one unit in BMI significantly elevates the risk of T2D by 28 % (Odds Ratio = 1.28, 95 % Confidence Interval [1.19, 1.37], p < .0001), commencing at a threshold of 18.5 kg/m2. This finding refutes the null hypothesis of no correlation between BMI and T2D.
CONCLUSION: The results of this analysis suggest that a BMI exceeding 18.5 kg/m2 may serve as a threshold for identifying individuals at an increased risk of T2D and for developing preventive strategies within the urban Asian Indian population. Nonetheless, this threshold warrants confirmation through a longitudinal investigation involving individuals with normal blood glucose levels, with particular attention to its correlation with HbA1c.