Медицинская библиотека · Neuro endocrinology letters · 2013

Poly (dextrogyr-levogyr) lactide acid-triiodothyronine scaffold for peripheral nerve regeneration.

Wang Min, Liu Chao, Hao Yong, Zhang Yuan, Zhang Xia

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Аннотация

OBJECTIVES

To evaluate the poly(dextrogyr-levogyr) lactide acid-triiodothyronine (PDLLA-T3) seeded with Schwann cells conduit for repairing sciatic nerve defect.

MATERIALS &

METHODS

The rats were divided into three groups: autologous nerve transplantation (Group A), PDLLA-T3 + Schwann cells (Group B) and PDLLA + Schwann cells (Group C).

RESULTS

Myelin sheath thickness was significantly greater in Group A compared with Group B and Group C. The regenerated nerves had nearly normal structure in Group A, and in Groups B and C nerve tissues filled in the anastomotic site and angiogenesis was noted. The mean number of myelinated nerve fibers and neurons in Group B was greater than in Group C.

CONCLUSIONS

PDLLA-T3 is superior to PDLLA alone for repairing nerve defects.

Для цитирования: Wang Min, Liu Chao, Hao Yong, Zhang Yuan, Zhang Xia. Poly (dextrogyr-levogyr) lactide acid-triiodothyronine scaffold for peripheral nerve regeneration.. Neuro endocrinology letters. 2013.

Предметные рубрики MeSH

Animals Axonal Transport Horseradish Peroxidase Lactic Acid Microscopy, Electron, Transmission Myelin Sheath Nerve Regeneration Polyesters Polymers Rats Rats, Sprague-Dawley S100 Proteins Schwann Cells Sciatic Nerve Sciatic Neuropathy Silver Staining Tissue Scaffolds Triiodothyronine

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