Journal of clinical periodontology · 2013
Genome-wide association study of chronic periodontitis in a general German population.
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Teumer Alexander, Holtfreter Birte, Völker Uwe, Petersmann Astrid, Nauck Matthias, Biffar Reiner, Völzke Henry, Kroemer Heyo K, Meisel Peter, Homuth Georg, Kocher Thomas
Аннотация
AIM: To identify loci associated with chronic periodontitis through a genome-wide association study (GWAS).
MATERIALS AND METHODS: A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n = 3365 and SHIP-TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome-based autosomal and X-chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed.
RESULTS: No genome-wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single SNP association reached genome-wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%.
CONCLUSIONS: No single SNPs were found to be genome-wide significantly associated with chronic periodontitis in this study.
MATERIALS AND METHODS: A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n = 3365 and SHIP-TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome-based autosomal and X-chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed.
RESULTS: No genome-wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single SNP association reached genome-wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%.
CONCLUSIONS: No single SNPs were found to be genome-wide significantly associated with chronic periodontitis in this study.
Предметные рубрики MeSH
AdenineAdultAge FactorsAgedAged, 80 and overChromosomes, Human, XChronic PeriodontitisCohort StudiesCross-Sectional StudiesCytosineFemaleFollow-Up StudiesGenetic VariationGenome-Wide Association StudyGenotypeGermanyHapMap ProjectHumansINDEL MutationMaleMiddle AgedPeriodontal Attachment LossPeriodontal PocketPolymorphism, Single NucleotidePopulation SurveillanceThymineYoung Adult