Acquired Oral Hyperpigmentation: A Benign Finding or a Malignant Clue?

Laugier-Hunziker syndrome (LHS) is a rare, acquired pigmentary disorder characterized by mucocutaneous hyperpigmentation, primarily affecting the oral mucosa and nails. We present a case of a 76-year-old male patient with extensive melanotic macules on the oral mucosa, lips, tongue, genitalia, and acral regions. Histopathological examination revealed basal layer hyperpigmentation and dermal melanophages. Systemic involvement was excluded through interdisciplinary evaluation. LHS, though benign, requires differentiation from syndromes with malignant potential, such as Peutz-Jeghers syndrome. This case underscores the importance of recognizing LHS to avoid unnecessary interventions and ensure appropriate patient reassurance.