The journal of venomous animals and toxins including tropical diseases · 2022
Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Jarrah Samar Afif, Kmetiuk Louise Bach, de Carvalho Otávio Valério, de Sousa Alessandra Tammy Hayakawa Ito, Souza Valeria Regia Franco, Nakazato Luciano, Colodel Edson Moleta, Dos Santos Andrea Pires, Pettan-Brewer Christina, Hahn Rosane Christine, Slhessarenko Renata Dezengrini, Ubiali Daniel Guimarães, Pereira Asheley Henrique Barbosa, de Morais Helio Autran, Biondo Alexander Welker, Dutra Valéria
Аннотация
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs.
CASE PRESENTATION: We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen.
CONCLUSION: The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.
CASE PRESENTATION: We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen.
CONCLUSION: The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.