Revista medica de Chile · 2004
[Results of the first Chilean registry of unstable angina. Clinical features, risk profile and treatment].
Аннотация на английскомСтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Corbalán Ramón, Nazzal Carolina, Eggers Germán, Bartolucci Jaime, Prieto Juan Carlos, Alcaíno Milton, Stockins Benjamín, Campos Pabla, Dapelo Alejandro, Grupo de Angina Inestable, Departamento de Estudios Multicéntricos, Sociedad Chilena de, Cardiología y Cirugía Cardiovascular
Аннотация
BACKGROUND: From January 2000 to June 2002, the first Chilean registry of unstable angina was carried out, with the participation of 15 hospitals.
AIM: To report the clinical and demographic features of 600 patients with unstable angina, their risk profile and prognosis.
MATERIAL AND METHODS: The inclusion criteria for this prospective registry were a history of recent onset of chest pain (<48 hours) or a change in the character of previous angina, associated to ischemic electrocardiographic changes and/or positive markers of myocardial damage.
RESULTS: Mean age of the patients was 65 years and 37% were women. Among coronary risk factors, 63% had hypertension, 27% had diabetes, 52% had dyslipidemia, 31% smoked and 21% had a family history of atherosclerosis. On admission 94% of patients had chest pain, associated to ST segment depression in 44%, negative T waves in 28% and positive markers of myocardial damage in 30%. Fifty seven percent received intravenous nitroglycerin, 47% received oral nitrates, 69% beta blockers and 15%, calcium antagonists. Antithrombotic therapy included aspirin in 96%, heparin in 74%, ticlodipine or clopidogrel in 19% and IIb/IIIa inhibitors in 12%. A coronary angiogram was performed in 52%, angioplasty in 25% and coronary bypass surgery in 13%. Hospital mortality was 2.6%. The incidence of new ischemic events was: myocardial infarction in 2.8% recurrent ischemia in 9.5% and refractory ischemia in 2%. The incidence of adverse events increased according to a higher risk profile.
CONCLUSIONS: The demographic and clinical features, treatment and mortality of these patients are similar to those reported in international registries, with a low mortality rate.
AIM: To report the clinical and demographic features of 600 patients with unstable angina, their risk profile and prognosis.
MATERIAL AND METHODS: The inclusion criteria for this prospective registry were a history of recent onset of chest pain (<48 hours) or a change in the character of previous angina, associated to ischemic electrocardiographic changes and/or positive markers of myocardial damage.
RESULTS: Mean age of the patients was 65 years and 37% were women. Among coronary risk factors, 63% had hypertension, 27% had diabetes, 52% had dyslipidemia, 31% smoked and 21% had a family history of atherosclerosis. On admission 94% of patients had chest pain, associated to ST segment depression in 44%, negative T waves in 28% and positive markers of myocardial damage in 30%. Fifty seven percent received intravenous nitroglycerin, 47% received oral nitrates, 69% beta blockers and 15%, calcium antagonists. Antithrombotic therapy included aspirin in 96%, heparin in 74%, ticlodipine or clopidogrel in 19% and IIb/IIIa inhibitors in 12%. A coronary angiogram was performed in 52%, angioplasty in 25% and coronary bypass surgery in 13%. Hospital mortality was 2.6%. The incidence of new ischemic events was: myocardial infarction in 2.8% recurrent ischemia in 9.5% and refractory ischemia in 2%. The incidence of adverse events increased according to a higher risk profile.
CONCLUSIONS: The demographic and clinical features, treatment and mortality of these patients are similar to those reported in international registries, with a low mortality rate.