Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA · 2004
[Comparative study of T cell proliferative response in different types of coronary heart diseases].
Сравнительное исследованиеАннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Zheng Hua, Wu Sai-zhu, Lai Wen-yan
Аннотация
OBJECTIVE: To investigate the association between proliferative response of T cells and plaque stability in coronary heart disease.
METHODS: A total of 66 subjects were recruited in the study, including 13 patients with acute myocardial infarction (AMI), 22 with unstable angina pectoris (UAP), 15 with stable angina pectoris (SAP) and 16 control subjects without coronary heart disease. The proliferative response of T cells to phytohemagglutinin (PHA), oxidized low-density lipoprotein (oxLDL) and low-density lipoprotein (LDL) was examined by MTS/PMS colorimetric assay.
RESULTS: Significantly stronger proliferative response of T cells to PHA was noted in AMI and UAP groups than in SAP and control groups (P<0.05), as with the response to oxLDL (at doses of 5 and 1 microg/ml, P<0.05). T cell proliferative response to oxLDL (at the doses of 10, 5 and 1 microg/ml) appeared significantly stronger than that to LDL (at the same dose as oxLDL) in AMI group and UAP group (P<0.05).
CONCLUSION: Cellular immunity mediated by T cells, especially the immune response to oxLDL, may play an important role in the instability of plaque and the occurrence of acute coronary syndrome (ACS).
METHODS: A total of 66 subjects were recruited in the study, including 13 patients with acute myocardial infarction (AMI), 22 with unstable angina pectoris (UAP), 15 with stable angina pectoris (SAP) and 16 control subjects without coronary heart disease. The proliferative response of T cells to phytohemagglutinin (PHA), oxidized low-density lipoprotein (oxLDL) and low-density lipoprotein (LDL) was examined by MTS/PMS colorimetric assay.
RESULTS: Significantly stronger proliferative response of T cells to PHA was noted in AMI and UAP groups than in SAP and control groups (P<0.05), as with the response to oxLDL (at doses of 5 and 1 microg/ml, P<0.05). T cell proliferative response to oxLDL (at the doses of 10, 5 and 1 microg/ml) appeared significantly stronger than that to LDL (at the same dose as oxLDL) in AMI group and UAP group (P<0.05).
CONCLUSION: Cellular immunity mediated by T cells, especially the immune response to oxLDL, may play an important role in the instability of plaque and the occurrence of acute coronary syndrome (ACS).