Head & neck · 2011
Intensity-modulated radiotherapy for locally advanced cancers of the larynx and hypopharynx.
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Daly Megan E, Le Quynh-Thu, Jain Anshu K, Maxim Peter G, Hsu Annie, Loo Billy W, Kaplan Michael J, Fischbein Nancy J, Colevas A Dimitrios, Pinto Harlan, Chang Daniel T
Аннотация
BACKGROUND: Limited data evaluate intensity-modulated radiotherapy (IMRT) for cancers of the hypopharynx and larynx. We report clinical outcomes and failure patterns for these patients.
METHODS: Between September 2001 and December 2007, 42 patients with squamous cell carcinoma (SCC) of the hypopharynx (n = 23) and larynx (n = 19) underwent IMRT, 11 postoperatively and 31 definitively. Thirty-six received systemic therapy. Median follow-up was 30 months among surviving patients.
RESULTS: Three local failures occurred within the high-dose region and 3 occurred in regional nodes. Seven patients developed distant metastasis as the initial failure. Three-year actuarial estimates of locoregional control, freedom from distant metastasis, and overall survival rates were, respectively, 80%, 72%, and 46%.
CONCLUSIONS: IMRT provides good locoregional control for SCC of the hypopharynx and larynx compared with historical controls. Locoregional relapses occurred in the high-dose volumes, suggesting adequate target volume delineation. Hypopharyngeal tumors, which fare worse than laryngeal tumors, warrant investigation of more aggressive treatment.
METHODS: Between September 2001 and December 2007, 42 patients with squamous cell carcinoma (SCC) of the hypopharynx (n = 23) and larynx (n = 19) underwent IMRT, 11 postoperatively and 31 definitively. Thirty-six received systemic therapy. Median follow-up was 30 months among surviving patients.
RESULTS: Three local failures occurred within the high-dose region and 3 occurred in regional nodes. Seven patients developed distant metastasis as the initial failure. Three-year actuarial estimates of locoregional control, freedom from distant metastasis, and overall survival rates were, respectively, 80%, 72%, and 46%.
CONCLUSIONS: IMRT provides good locoregional control for SCC of the hypopharynx and larynx compared with historical controls. Locoregional relapses occurred in the high-dose volumes, suggesting adequate target volume delineation. Hypopharyngeal tumors, which fare worse than laryngeal tumors, warrant investigation of more aggressive treatment.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overBiopsy, NeedleCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalDose-Response Relationship, RadiationFemaleFollow-Up StudiesHumansHypopharyngeal NeoplasmsKaplan-Meier EstimateLaryngeal NeoplasmsLaryngectomyLaryngoscopyMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingRadiation InjuriesRadiotherapy, AdjuvantRadiotherapy, Intensity-ModulatedRetrospective StudiesRisk AssessmentStatistics, NonparametricSurvival RateTreatment OutcomeYoung Adult