Molecular immunology · 2026
The association of systemic immune-inflammation index with Th17/Treg imbalance, disease severity (PASI), and quality of life (DLQI/PLSI) in patients with psoriasis vulgaris: A cross-sectional study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lin Ling, Li Wei, Gao Xinjing, Li Qian, Zhou Xin, Liu Weiyu, Zhong Xuelian, Yang Yunqing, Zhang Xibao, Luo Quan
Аннотация
OBJECTIVE: This cross-sectional observational study aimed to investigate the relationship between systemic immune-inflammation index (SII) and Th17/Treg cell imbalance in psoriasis vulgaris (PV) at a specific timepoint (upon admission), as well as its predictive value for disease severity.
METHODS: A total of 112 PV patients and 112 healthy controls were enrolled. Blood cell counts were used to calculate SII. Levels of Th17/Treg cells, cytokines (IL-17, IL-22, IL-10, TGF-β1), disease severity (PASI), and related factors were analyzed. Patients were classified into mild (MPV) or moderate-to-severe (MSPV) groups, and logistic regression identified independent risk factors for severity.
RESULTS: PV patients showed elevated neutrophils, SII, Th17, IL-17, and IL-22, but reduced lymphocytes, Treg, IL-10, and TGF-β1. SII positively correlated with PASI. MSPV patients had higher BMI, SII, Th17/Treg ratio, and cytokines (P < 0.05). BMI, SII, and Th17/Treg ratio were independent predictors of severity.
CONCLUSION: This cross-sectional study indicates significant correlations of elevated SII levels in PV patients at a specific timepoint (upon admission) with Th17/Treg imbalance, disease severity (PASI), and poorer quality of life (DLQI/PLSI). These findings suggest the possibility of SII at a specific timepoint (upon admission) as a "snapshot" biomarker of the immuno-inflammatory status in PV.
METHODS: A total of 112 PV patients and 112 healthy controls were enrolled. Blood cell counts were used to calculate SII. Levels of Th17/Treg cells, cytokines (IL-17, IL-22, IL-10, TGF-β1), disease severity (PASI), and related factors were analyzed. Patients were classified into mild (MPV) or moderate-to-severe (MSPV) groups, and logistic regression identified independent risk factors for severity.
RESULTS: PV patients showed elevated neutrophils, SII, Th17, IL-17, and IL-22, but reduced lymphocytes, Treg, IL-10, and TGF-β1. SII positively correlated with PASI. MSPV patients had higher BMI, SII, Th17/Treg ratio, and cytokines (P < 0.05). BMI, SII, and Th17/Treg ratio were independent predictors of severity.
CONCLUSION: This cross-sectional study indicates significant correlations of elevated SII levels in PV patients at a specific timepoint (upon admission) with Th17/Treg imbalance, disease severity (PASI), and poorer quality of life (DLQI/PLSI). These findings suggest the possibility of SII at a specific timepoint (upon admission) as a "snapshot" biomarker of the immuno-inflammatory status in PV.