Diabetes research and clinical practice · 2025
Effectiveness of probiotic therapy as an adjunct in the management of periodontal disease in type 2 diabetics: A systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Yuqi Wang, Hangying Xu, Ruyi Yan, Xiaolan Zhang, Yajing Chen
Аннотация
BACKGROUND: Periodontal disease and diabetes mellitus are chronic diseases with a high global prevalence and are closely associated. Adjunctive probiotic therapy has garnered increasing attention in the management of type 2 diabetes mellitus (T2DM) with periodontal disease.
OBJECTIVE: This review elucidates the effect of probiotic therapy on inflammatory markers, periodontal parameters, and glycated hemoglobin (HbA1c) in people with both T2DM and periodontal disease.
METHODS: A comprehensive literature search was conducted across seven electronic databases from their inception to June 08, 2025. Randomized controlled trials (RCTs) and quasi-experimental studies (QERs) comparing adjunctive probiotic therapy and Non-Surgical Periodontal Treatment (NSPT) monotherapy were selected. Two reviewers independently screened studies, extracted data, and assessed the risk of bias using the Cochrane Risk of Bias 2 (RoB 2) tool for RCTs and the Joanna Briggs Institute (JBI) critical appraisal tool for QERs.
RESULTS: Seven studies (five RCTs and two QERs) involving 514 patients were included. Compared with NSPT monotherapy, adjunctive probiotic therapy improved interleukin-6 (IL-6) levels (standardized mean difference [SMD] -1.07; 95 % CI: -1.91 to -0.24; P = 0.01) and probing depth (SMD -1.13, 95 % CI: -2.19 to -0.07, p = 0.04).
CONCLUSION: Adjunctive probiotic therapy effectively reduces IL-6 levels and probing depth in patients with T2DM complicated by periodontal disease.
OBJECTIVE: This review elucidates the effect of probiotic therapy on inflammatory markers, periodontal parameters, and glycated hemoglobin (HbA1c) in people with both T2DM and periodontal disease.
METHODS: A comprehensive literature search was conducted across seven electronic databases from their inception to June 08, 2025. Randomized controlled trials (RCTs) and quasi-experimental studies (QERs) comparing adjunctive probiotic therapy and Non-Surgical Periodontal Treatment (NSPT) monotherapy were selected. Two reviewers independently screened studies, extracted data, and assessed the risk of bias using the Cochrane Risk of Bias 2 (RoB 2) tool for RCTs and the Joanna Briggs Institute (JBI) critical appraisal tool for QERs.
RESULTS: Seven studies (five RCTs and two QERs) involving 514 patients were included. Compared with NSPT monotherapy, adjunctive probiotic therapy improved interleukin-6 (IL-6) levels (standardized mean difference [SMD] -1.07; 95 % CI: -1.91 to -0.24; P = 0.01) and probing depth (SMD -1.13, 95 % CI: -2.19 to -0.07, p = 0.04).
CONCLUSION: Adjunctive probiotic therapy effectively reduces IL-6 levels and probing depth in patients with T2DM complicated by periodontal disease.