[Nihon koshu eisei zasshi] Japanese journal of public health · 2010
[Literature review on the association between inactivated influenza vaccines and the Guillain-Barré syndrome].
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Kobayashi Masayuki, Takechi Maria, Kondo Kyoko, Ohfuji Satoko, Fukushima Wakaba, Maeda Akiko, Hirota Yoshio
Аннотация
PURPOSE: To summarize data on associations between inactivated influenza vaccines and the Guillain-Barré syndrome.
METHODS: The association between inactivated influenza vaccines and the Guillain-Barré syndrome was described and discussed, mainly on the basis of previous studies cited in "Prevention and Control of Influenza: Recommendations of the Advisory Committee on Immunization Practices".
RESULTS: The A/New Jersey/76 swine influenza vaccine has been reported to be associated with occurrence of the Guillain-Barré syndrome. However, it is unclear whether seasonal inactivated influenza vaccines are associated with the occurrence of the syndrome. According to a study from the United States, which reported a statistically significant association between seasonal inactivated influenza vaccines and Guillain-Barré syndrome, the best estimate of maximum attributable risk, after allowing for study limitations, is 1.6 cases per million vaccinations.
DISCUSSION: We could not draw any definite conclusions about any causal relationship between seasonal influenza vaccination and the Guillain-Barré syndrome. Therefore we considering the estimated benefits of seasonal influenza vaccination to outweigh the reported risk of subsequent development of the Guillain-Barré syndrome.
METHODS: The association between inactivated influenza vaccines and the Guillain-Barré syndrome was described and discussed, mainly on the basis of previous studies cited in "Prevention and Control of Influenza: Recommendations of the Advisory Committee on Immunization Practices".
RESULTS: The A/New Jersey/76 swine influenza vaccine has been reported to be associated with occurrence of the Guillain-Barré syndrome. However, it is unclear whether seasonal inactivated influenza vaccines are associated with the occurrence of the syndrome. According to a study from the United States, which reported a statistically significant association between seasonal inactivated influenza vaccines and Guillain-Barré syndrome, the best estimate of maximum attributable risk, after allowing for study limitations, is 1.6 cases per million vaccinations.
DISCUSSION: We could not draw any definite conclusions about any causal relationship between seasonal influenza vaccination and the Guillain-Barré syndrome. Therefore we considering the estimated benefits of seasonal influenza vaccination to outweigh the reported risk of subsequent development of the Guillain-Barré syndrome.