Oral diseases · 2025
Clinical Applications and Mechanisms of Klotho in Periodontitis Diagnosis and Therapy.
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Wan Chengyu, Yang Yalan, Wang Bozhao, Li Jian
Аннотация
OBJECTIVES: Periodontitis is a prevalent chronic inflammatory condition affecting the periodontal supporting tissue, and Klotho has anti-inflammatory and antioxidant effects. In recent years, some emerging evidence has revealed a link between Klotho and periodontitis. This review aims to elucidate the effects of Klotho in periodontitis and summarize the methods to increase Klotho levels for clinical treatment.
SUBJECTS AND METHODS: We conducted a systematic search of PubMed, Web of Science, and Embase databases to review the current research status of Klotho in relation to periodontitis and its roles in periodontal disease mechanisms.
RESULTS: Klotho demonstrates anti-inflammatory, antioxidant, autophagy-enhancing, and alveolar bone regeneration-promoting effects in periodontitis. Feasible strategies to elevate Klotho levels in humans include exogenous supplementation of Klotho and modulation of its upstream regulatory pathways.
CONCLUSION: Klotho and its associated enhancers show significant therapeutic potential for the management of periodontitis; however, the underlying mechanisms and more clinical studies are still lacking, and further research is needed.
SUBJECTS AND METHODS: We conducted a systematic search of PubMed, Web of Science, and Embase databases to review the current research status of Klotho in relation to periodontitis and its roles in periodontal disease mechanisms.
RESULTS: Klotho demonstrates anti-inflammatory, antioxidant, autophagy-enhancing, and alveolar bone regeneration-promoting effects in periodontitis. Feasible strategies to elevate Klotho levels in humans include exogenous supplementation of Klotho and modulation of its upstream regulatory pathways.
CONCLUSION: Klotho and its associated enhancers show significant therapeutic potential for the management of periodontitis; however, the underlying mechanisms and more clinical studies are still lacking, and further research is needed.