Clinical Applications and Mechanisms of Klotho in Periodontitis Diagnosis and Therapy.

OBJECTIVES

Periodontitis is a prevalent chronic inflammatory condition affecting the periodontal supporting tissue, and Klotho has anti-inflammatory and antioxidant effects. In recent years, some emerging evidence has revealed a link between Klotho and periodontitis. This review aims to elucidate the effects of Klotho in periodontitis and summarize the methods to increase Klotho levels for clinical treatment.

SUBJECTS AND

METHODS

We conducted a systematic search of PubMed, Web of Science, and Embase databases to review the current research status of Klotho in relation to periodontitis and its roles in periodontal disease mechanisms.

RESULTS

Klotho demonstrates anti-inflammatory, antioxidant, autophagy-enhancing, and alveolar bone regeneration-promoting effects in periodontitis. Feasible strategies to elevate Klotho levels in humans include exogenous supplementation of Klotho and modulation of its upstream regulatory pathways.

CONCLUSION

Klotho and its associated enhancers show significant therapeutic potential for the management of periodontitis; however, the underlying mechanisms and more clinical studies are still lacking, and further research is needed.