Biochemical and biophysical research communications · 2010
MMP-mediated cleavage of beta-dystroglycan in myelin sheath is involved in autoimmune neuritis.
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Zhao Xiu Li, Li Guo Zhong, Sun Bo, Zhang Zhong Ling, Yin Yan Hong, Tian Yu Shuang, Li He, Li Hu Lun, Wang De Sheng, Zhong Di
Аннотация
Alpha-/beta-dystroglycans (DG) located at the outmost layer of myelin sheath play a critical role in its formation and stability in the peripheral nerve system. The demyelination of nerve fibers is present in autoimmune neuritis, however, it is not known about the molecular mechanisms underlying this pathological process. In an animal model of experimental autoimmune neuritis, we observed that beta-DG cleavage was associated with the demyelination of peripheral nerves. The neuritis and beta-DG cleavage were accompanied by matrix metalloproteinase (MMP)-2/-9 over-expressions and attenuated by captopril, a MMP inhibitor. The blockade of MMPs also improves clinical signs. Our results reveal a crucial role of MMP-mediated beta-DG cleavage in autoimmune neuritis, such as Guillain-Barre' syndrome, and bring insights into therapeutic strategies for autoimmune diseases.