Cell reports · 2012
Hypomethylation of the IL17RC promoter associates with age-related macular degeneration.
СтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wei Lai, Liu Baoying, Tuo Jingsheng, Shen Defen, Chen Ping, Li Zhiyu, Liu Xunxian, Ni Jia, Dagur Pradeep, Sen H Nida, Jawad Shayma, Ling Diamond, Park Stanley, Chakrabarty Sagarika, Meyerle Catherine, Agron Elvira, Ferris Frederick L, Chew Emily Y, McCoy J Philip, Blum Emily, Francis Peter J, Klein Michael L, Guymer Robyn H, Baird Paul N, Chan Chi-Chao, Nussenblatt Robert B
Аннотация
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis.