Mediterranean journal of hematology and infectious diseases · 2012
Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases.
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D'Arena Giovanni, Rossi Giovanni, Vannata Barbara, Deaglio Silvia, Mansueto Giovanna, D'Auria Fiorella, Statuto Teodora, Simeon Vittorio, De Martino Laura, Marandino Aurelio, Del Poeta8 Giovanni, De Feo Vincenzo, Musto Pellegrino
Аннотация
Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL). Their number correlates with more aggressive disease status and is predictive of the time to treatment, as well. Moreover, it is now clear that dysregulation in Tregs cell frequency and/or function may result in a plethora of autoimmune diseases, including multiple sclerosis, type 1 diabetes mellitus, myasthenia gravis, systemic lupus erythematosus, autoimmune lymphoproliferative disorders, rheumatoid arthritis, and psoriasis. Efforts are made aiming to develop approaches to deplete Tregs or inhibit their function in cancer and autoimmune disorders, as well.