Diabetes research and clinical practice · 2025
Lived experience of fully closed-loop insulin delivery in adolescents with type 1 diabetes and HbA1c above target.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kadiyala Nithya, Allen Janet, Lakshman Rama, Boughton Charlotte K, Wilinska Malgorzata E, Thankamony Ajay, Hartnell Sara, Thabit Hood, Willemsen Ruben H, Shah Pratik, Ware Julia, Hovorka Roman
Аннотация
AIMS: The aim of this qualitative study was to explore the impact of using the CamAPS HX fully closed-loop system, which does not require carbohydrate counting, meal announcements or pre-meal bolusing, on the daily lives of adolescents with type 1 diabetes and HbA1c above the recommended target (≥7.5 % [58 mmol/mol]).
METHODS: Twelve adolescents took part in virtual semi-structured interviews. Data was analyzed thematically using an inductive-deductive approach. Study participants also completed quality of life questionnaires.
RESULTS: All interviewees reported reduced effort in managing diabetes, as they no longer needed to count carbohydrates or bolus, and worried less about their glucose levels. This led to improved quality of life, with a greater sense of freedom and normalcy, particularly around meals. A few also noted benefits in physical activity, sleep, work and social life. Interviewees expressed dissatisfaction with the algorithm's slow response to postprandial glucose spikes, and the need for a tethered pump. Questionnaires showed no significant differences in hypoglycaemia fear or diabetes distress between study periods but reflected a positive experience with the closed-loop system.
CONCLUSIONS: In adolescents with type 1 diabetes, fully closed-loop insulin delivery reduced the daily burden of self-management, leading to improved quality of life.
CLINICAL TRIAL REGISTRATION: NCT05653050.
METHODS: Twelve adolescents took part in virtual semi-structured interviews. Data was analyzed thematically using an inductive-deductive approach. Study participants also completed quality of life questionnaires.
RESULTS: All interviewees reported reduced effort in managing diabetes, as they no longer needed to count carbohydrates or bolus, and worried less about their glucose levels. This led to improved quality of life, with a greater sense of freedom and normalcy, particularly around meals. A few also noted benefits in physical activity, sleep, work and social life. Interviewees expressed dissatisfaction with the algorithm's slow response to postprandial glucose spikes, and the need for a tethered pump. Questionnaires showed no significant differences in hypoglycaemia fear or diabetes distress between study periods but reflected a positive experience with the closed-loop system.
CONCLUSIONS: In adolescents with type 1 diabetes, fully closed-loop insulin delivery reduced the daily burden of self-management, leading to improved quality of life.
CLINICAL TRIAL REGISTRATION: NCT05653050.