Functional Evaluation of Irreversible Electroporation for a Pancreatic Nonfunctioning Neuroendocrine Tumor Using 68 Ga-DOTATOC PET/CT.

Percutaneous irreversible electroporation (IRE) is a nonthermal ablation technique increasingly used for pancreatic malignancies, though rarely reported in pancreatic neuroendocrine tumors (pNETs). We present the case of a 75-year-old man with a well-differentiated grade-1 nonfunctioning pNET treated by percutaneous IRE after refusing surgery. Posttreatment somatostatin receptors PET/CT showed a marked reduction in 68 Ga-DOTATOC uptake at 1 month, followed by stable residual activity at 1 year, despite complete devascularization on contrast-enhanced CT. This case illustrates the potential of IRE to achieve durable tumor control and highlights the added value of PET/CT in assessing functional response beyond morphology.