Pharmacogenomics · 2015
Effect of clinical factors and gene polymorphism of CYP2C19*2, *17 and CYP4F2*3 on early stent thrombosis.
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Kupstyte Nora, Zaliunas Remigijus, Tatarunas Vacis, Skipskis Vilius, Zaliaduonyte-Peksiene Diana, Grabauskyte Ingrida, Dovidaitiene Dovile, Bumblauskas Karolis, Gustiene Olivija, Lesauskaite Vaiva
Аннотация
AIM: To determine the main clinical and genetic factors having impact on early coronary stent thrombosis.
MATERIALS & METHODS: Genotyping of CYP2C19*2, *17 and CYP4F2*3 in patients with (n = 31) and without stent thrombosis (n = 456) was performed. Clinical and genetic data were analyzed by binary logistic regression.
RESULTS: Smoking (OR: 0.317; 95% CI: 0.131-0.767), high-density lipoprotein level in mmol/l (OR: 0.142; 95% CI: 0.040-0.506), CYP2C19*2*2 versus *1*1 and *1*2 genotype (OR: 11.625; 95% CI: 3.498-38.633), CYP4F2 AA versus GA and GG genotype (OR: 3.532; 95% CI: 1.153-10.822) were associated with early stent thrombosis.
CONCLUSION: For the first time we have identified a clinically important polymorphism (CYP4F2 G1347A) that was independently associated with early stent thrombosis. Original submitted 18 August 2014; Revision submitted 10 November 2014.
MATERIALS & METHODS: Genotyping of CYP2C19*2, *17 and CYP4F2*3 in patients with (n = 31) and without stent thrombosis (n = 456) was performed. Clinical and genetic data were analyzed by binary logistic regression.
RESULTS: Smoking (OR: 0.317; 95% CI: 0.131-0.767), high-density lipoprotein level in mmol/l (OR: 0.142; 95% CI: 0.040-0.506), CYP2C19*2*2 versus *1*1 and *1*2 genotype (OR: 11.625; 95% CI: 3.498-38.633), CYP4F2 AA versus GA and GG genotype (OR: 3.532; 95% CI: 1.153-10.822) were associated with early stent thrombosis.
CONCLUSION: For the first time we have identified a clinically important polymorphism (CYP4F2 G1347A) that was independently associated with early stent thrombosis. Original submitted 18 August 2014; Revision submitted 10 November 2014.
Предметные рубрики MeSH
AgedAspirinCase-Control StudiesClopidogrelCytochrome P-450 CYP2C19Cytochrome P-450 Enzyme SystemCytochrome P450 Family 4FemaleGenotypeHumansLogistic ModelsMaleMiddle AgedModels, GeneticPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPolymorphism, GeneticRisk FactorsStentsThrombosisTiclopidine