Catalase-assembled nanoparticles for PA/CT dual-modality imaging and repair of acute alcoholic gastritis.

The development of simple, rapid, sensitive and noninvasive theranostic agents for acute gastritis is crucial. Herein, an engineering catalase-conjugated bismuth nanoparticle was fabricated for near-infrared photoacoustic imaging and computed tomography imaging of acute alcoholic gastritis. This nanoparticle could quickly respond to H2O2 and H+ overexpressed in the microenvironment of acute gastritis in mice, emitting strong signals for precise localization. Additionally, it adhered to the damaged gastric mucosa for an extended period, acting as a long-acting mucosal protector by inhibiting related inflammatory reactions and promoting mucosal repair. The use of this catalase-assembled nanoparticle could extend its residence time in the stomach, thereby reducing the drug dose and treatment duration. These findings of our study underscored the potential of this multifunctional nanoplatform for integrated diagnosis and treatment of gastrointestinal inflammatory diseases.